Fenbendazole is a broad-spectrum benzimidazole with antiparasitic activity. It is used to treat nematode diseases in fish and other livestock species, and can also be used for gastrointestinal parasites in dogs, cats, and horses. It is also being researched for its potential to complement conventional cancer treatment methods.
In vivo and cell culture studies have shown that high doses of fenbendazole are toxic to EMT6 mammary tumor cells in vitro, and that the toxicity increases with incubation time and under hypoxic conditions. When fenbendazole was added to maximally intensive regimens of paclitaxel and radiation in the treatment of EMT6 mammary carcinomas in mice, it significantly enhanced the antineoplastic effects of those drugs, but did not affect their cytotoxic effects alone.
Animals treated with fenbendazole at regular dosages usually do not experience any side effects. However, animals may develop an allergic reaction (facial swelling, itchiness, hives, swollen lips or tongue, vomiting, diarrhea or shock) to the drug at higher than normal dosages. It is important to give the medication exactly as directed by your veterinarian.
When administering fenbendazole, it is recommended to mix the drug with sterile, pyrogen-free physiologic saline and inject it i.p. Animals to be irradiated were anesthetized with 100 mg/kg ketamine plus 10 mg/kg xylazine and their tumors irradiated locally with 10 Gy of 250 kV X-rays on a Siemens Stabilipan irradiator (Malvern, PA). The bodies and limbs of the mice were shielded so that critical normal tissues received less than 0.5 Gy of radiation. fenbendazole 222mg capsules for humans